- Charles Clinton Abbey
- Built the Boston Arena (now Matthew Arena), the oldest arena still in use for hockey.
- David Francis Bohr
- Leading researcher in the area of hypertension
- Tyrus Raymond Cobb
- Hall of Fame Major League Baseball Player; "The Georgia Peach"
- Ivy Frances Nichols Payne Crane
- Famous dancer during the 1920's; edited the series of books entitled "The Hollywood Album"
- Lewis Douglas Crane
- Famous dancer during the 1920's
- Percival Lynwood Harden
- Owner and publisher of the Club Fellow and Washington Mirror (society scandal publications); reputed to have been the originator of the agency system of advertising; committted suicide.
- Thomas Hinckley
- Governor of Plymouth Colony, 1680-1686, 1689-1692
- William Fowler Hopson
- Engraver/illustrator. Illustrated Webster's Dictionary in the late 1800s; illustrated a number of books and had exhibitions in England, Paris, Italy and Spain.
- Sebastian Spering Kresge
- Creator and owner of two chains of department stores, one of which (Kresge-Newark) was renamed KMart Holdings.in 1977.
- L.L.L.
- Only woman on the payroll of United States Centennial Commission in Philadelphia in the late 1870s-early 1880s. She wrote for Harper's and newspapers under the pseudonyms of Lillie Lull and L.L.L.
- Jonathan Lambert
- First documented deaf individual on Martha's Vineyard and one of the first users/originators of Martha's Vineyard Sign Language. Two of his children were also deaf.
- Winfield Scott Limes
- Business agent of AFL-Wood, Wire and Metal Lathers, Local 171; founder of the international union and its first president of the first local, No. 1., in Columbus, Ohio.
- Lillie Lull
- Only woman on the payroll of United States Centennial Commission in Philadelphia in the late 1870s-early 1880s. She wrote for Harper's and newspapers under the pseudonyms of Lillie Lull and L.L.L.
- Alvin Orlando Lombard
- Invented the Lombard steam log hauler, which was the original crawler-type overland tractor and led to the crawler-tread vehicles used today in construction, agricultural and military equipment.
- Azro Clark Lumbard
- Taught Mark Twain the printing trade. Started a number of newspapers, including Tioga Express, Millerton Advertiser and Wellsboro (PA) Agitator.
- Benjamin Lombard
- Banker whose donation to Illinois Liberal Institute after a fire allowed it to continue to develop. The school was renamed Lombard University in 1899; it is now Knox College.
- Eliot Howland Lumbard
- Helped create the New York City Police Foundation, NYSIIS (first criminal justice database to include criminal histories), the School of Criminal Justice at Albany and the American Maritime History Project at the U.S. Merchant Marine Academy
- Emily Frances Lombard Abbey Dunning Gill
- Philanthropist
- Frank C. Lumbard
- Famous singer during the Civil War
- Harry Clyde Lombard
- Radio entertainer
- Herbert Luther Lombard
- Internationally known pioneer in cancer research and treatment
- James Lewis Lombard
- International banker
- Dr. Joseph Edward Lumbard
- Pioneered medical advances in anesthesiology and invented medical devices
- Joseph Edward Lumbard, Jr.
- United States Circuit Judge; assisted in setting up the Office of Strategic Services, which later became the Central Intelligence Agency
- Jules. G. Lumbard
- Famous singer during the Civil War
- Lela Margaret Fairchild Lombard
- Radio entertainer
- Peter Kirk Lombard
- Broadway actor
- Susan M. Lombard
- Regent of Ellensburg Normal School
- Mabel Doris Mercer
- Chorus girl who became "Princess Farid Es Sultaneh" after her third marriage to a Persian prince; known for her extensive jewelry collection.
- Jencks Mowry
- Mathematician/teacher who started Mount Pleasant Academy, a private grammar school in Providence, RI.
- John Barton Oxford
- Author
- Richard Barker Shelton
- Author
- Belinda Lull Simmons Phillips Lombard
- Only woman on the payroll of United States Centennial Commission in Philadelphia in the late 1870s-early 1880s. She wrote for Harper's and newspapers under the pseudonyms of Lillie Lull and L.L.L.
- Capt. David Smith
- One of the first men to travel as far as the Falkland islands from Cape Cod in the mid-late 1700s in pursuit of whales
- Elliot Miriat Weisgarber
- World-reknown musical composer
- Wallace Humphrey White Jr.
- United States Congressman and Senator